Klotho proteins have been the subject of increasing interest for their potential role in slowing the aging process and treating various pathological conditions. In recent days the news has gone around the world that the American billionaire Bryan Johnson, keeping his Alpha Klotho index high, lowered his physical age to 21 in five months. In this article, we will explore the main agonists of Klotho proteins and their potential therapeutic impact.
Functions of Klotho proteins
Klotho proteins are a family of proteins involved in several physiological processes, including the control of aging and the regulation of phosphorus and calcium metabolism and vitamin D. Their name derives from Clotho, one of the three Moirai of Greek mythology, who weaved human destiny. Klotho proteins have been associated with increased longevity and better health, and their deficiency has been linked to several pathologies, including kidney and cardiovascular diseases.
Role of Klotho proteins in aging
Their expression and function appear to influence several biological processes related to aging, opening new perspectives for the development of anti-aging therapies . The mechanisms of action of Klotho proteins through which they influence cellular and tissue physiology are emerging as a key topic of research.
Health benefits of Klotho proteins
These proteins have been associated with improved kidney function , increased resistance to cardiovascular disease, and even increased longevity. Klotho protein deficiency has been linked to several pathological conditions, including renal disease, cardiovascular disorders, and ectopic ossification.
Expression of Klotho proteins in human tissues
Klotho proteins are expressed in various human tissues, including kidney, brain, heart, and vascular tissues. Understanding tissue expression patterns can provide valuable insights into their physiological functions and implications for human health.
Interactions of Klotho proteins with other growth factors and hormones
Klotho proteins interact with various growth factors and hormones, influencing a wide range of biological processes. Delving deeper into the interactions between Klotho proteins and other cellular signals may lead to a better understanding of their function and effects on health.
Promising Agonists of Klotho Proteins
SARTANS (Anti-hypertensive drugs)
Inhibitors such as losartan and valsartan have demonstrated the ability to increase Klotho expression, suggesting possible anti-aging and cardiovascular benefits.
STATINS (anti-cholesterol drugs)
Fluvastatin, a statin, has been associated with increased Klotho expression, paving the way for potential positive effects on longevity and cardiovascular health.
ANTI HYPERGLYCEMICS
Metformin, GLP-1-based agonists, GABA, and PPAR-γ agonists have been linked to increased Klotho expression, suggesting possible benefits in the treatment of diabetic conditions and aging.
NATURAL COMPOUNDS
Substances such as astaxanthin, curcumin, ginseng, ligustilide but in particular:
Resveratrol : Resveratrol is known to activate the signaling pathway mediated by the activating transcription factor 3/c-Jun complex, which in turn can increase the expression of the Klotho gene. This mechanism could lead to increased levels of Klotho protein in the body.
Curcumin : Curcumin has been shown to have antioxidant and anti-inflammatory properties that can positively influence the expression of the Klotho protein. Curcumin's exact effect on Klotho production may be linked to its ability to reduce oxidative stress and inflammation, which in turn could promote Klotho protein expression.
Quercetin : Quercetin, a flavonoid found in various foods including capers and onion, could influence the production of Klotho protein through its antioxidant and anti-inflammatory properties. By reducing oxidative stress and inflammation in the body, quercetin may promote a cellular environment that supports the expression of the Klotho protein.
In conclusion, Klotho protein agonists represent a promising area of research for the treatment of aging and various pathological conditions. The identification and development of drugs capable of modulating Klotho expression could open new avenues in the fight against age-related diseases and in improving quality of life. Further studies are needed to fully understand the therapeutic potential of these agonists and to translate these findings into new treatment options for patients.
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